Our sense of orientation is probably one of the greatest abilities of the human body. The world's ability to manipulate and lie to this ability is probably one of its greatest weaknesses.
The IMSAFE checklist is a personal checklist to help pilots determine if they are physically, mentally, and emotionally ready to perform the duties of flight.
Hypoxia is a major concern in the flight environment due to aircraft being capable of reaching altitudes where it is no longer possible to maintain an adequate level of oxygen in the body.